Deprax is a second generation antidepressant medication . Its active substance is trazodone and is used to treat chronic depression, insomnia and anxiety states. Thus, although the advantage of this psychotropic drug is undoubtedly in its action, more or less quickly, we can not ignore those side effects that, as always, must be taken into account.
Deprax has been with us for almost 60 years. It was discovered and developed commercially in Italy in 1961, when an attempt was made to find another therapeutic alternative, another so-called second-generation drug that acts as a selective inhibitor of serotonin reuptake (SSRI). The result was this capsule, usually pink, so prescribed until not long ago.
The manufacturer usually points out in the package leaflet its main benefit: its effectiveness during the first week of administration. In addition, another fact that many patients sought at one time, namely, using an antidepressant drug that does not favor weight gain, is added . On the other hand, to these supposed virtues, one more was worth mentioning, one that made Deprax one of the most sold drugs during the 70s and 80s: it was one of the most economical drugs.
However, something that was evident in those early years was one of its main side effects: orthostatic hypotension (low tension when the person stands up). Little by little, it was discovered that trazadone was much more effective and safe in smaller doses. This adjustment has allowed us to continue to help us effectively in the treatment of various conditions to this day.
Deprax, how does it work and what is it used for?Something that neurologists and psychiatrists tell us is that the brain is much more complicated than we think. To this day, we still do not know how antidepressants really work, and it is not always possible to predict which type of drug is the most appropriate 100% for each patient. Thus, the Deprax, despite having been in our market for almost six decades, continues to have defenders and detractors . Some people warn of its side effects, often unpredictable. However, there is no shortage of studies that reveal its great efficacy in different disorders.
Let's see now in what clinical conditions Deprax is usually prescribed.
How does Deprax work?
As we have pointed out, Deprax is a second generation drug, that is, it acts as an antagonist and inhibitor of serotonin reuptake. Now, what differentiates this drug from Prozac , for example, is that we are dealing with a chemical compound of the phenylpiperazine family . This translates into some advantages and other disadvantages. The benefit is that it is a 5-HT receptor inhibitor. This means that their action to treat anxiety and depression is high.
Now, what it does is also block alpha adrenergic receptors and serotonin transport proteins . All this can lead to a wide range of side effects, although of little severity.
Side effects of Deprax
There are patients who take Deprax without evidencing any side effect. Other people, on the other hand, tend to show some problem, some alteration that can usually be due to other conditions (certain diseases, interaction with other drugs or foods, etc.). Thus, something that should be taken into account is that this drug is not recommended in people with liver, heart or kidney problems.
In addition, it can not be taken in combination with other sedatives, heart drugs, antibiotics, anticoagulants or even drugs of natural medicine such as St. John's wort . We must follow every indication of the doctors to the letter.
Let's see now what are the main side effects .
At present we already have newer, safer drugs with less secondary symptoms . However, options such as Deprax are still common in psychiatric practice for one reason: when we have patients with concomitant depressions, that is, accompanied by anxiety, insomnia, nightmares and psychological distress, this medication is one of the most effective.